The predecessor of the hospital was Hefei Christ Hospital. It was founded in 1898. After the baptism of wind and rain, it has developed into a province with advanced equipment, complete specialties, and strong technical force, integrating medical treatment, teaching, scientific research, prevention, health care, rehabilitation, and first aid The first-level large-scale tertiary-level A comprehensive hospital ranks 79th in the Fudan University Hospital Ranking. Currently, it is under the dual management of the University of Science and Technology of China and the Anhui Provincial Health Commission, with the management of the University of Science and Technology of China as the main management.

The hospital consists of the General Hospital (Headquarters), Southern District (Anhui Brain Hospital, Anhui Cardiovascular Hospital), West District (Anhui Cancer Hospital), Infectious Disease Hospital (Hefei Infectious Disease Hospital) and Reproductive and Genetic Branch. Geriatric Rehabilitation Center and Beicheng Hospital are under construction. At present, the total area (including planned area) is 1,158 mu, the total built-up area is 686,500 square meters, and the total under-construction area (excluding planned building area) is 514,300 square meters. The total establishment is 2,200 beds, 5,450 open beds, and 61 clinical medical technical departments. In 2019, the total number of outpatient and emergency visits was 5.0894 million, 281,000 were discharged from hospital, and 123,200 surgeries were performed. The "Regional Medical Center Collaborative Medical Strategic Network" was established in 2009. So far, it has established strategic synergies with 69 county and city hospitals inside and outside the province. Fully trust the Changfeng County People's Hospital to establish a provincial and county medical community, and trust Baohe District Wanghucheng Community Medical Service Center to establish a community medical community.

There are 7,076 employees in the hospital, including 1013 with senior professional titles. Full-time introduction of Professor Nashan, Chairman of the European Transplant Association. There are 6 specially-appointed academicians, 11 national-level talent titles, 115 State Council and provincial government subsidized experts, 49 "Jianghuai Famous Doctors", 4 provincial-level talent titles, 47 provincial academic and technical leaders and 61 reserve candidates. There are 24 chief physicians.

The hospital currently has 6 national key clinical specialty construction projects, 17 provincial "Twelfth Five-Year" clinical key specialties and 9 cultivation specialties; 5 "115" industrial innovation teams in Anhui Province. Key technologies such as transplantation technology, minimally invasive technology, interventional technology, critically ill treatment technology, cell transplantation and treatment technology are carried out in multiple disciplines. It is shortlisted for 2 projects of the National Diagnosis and Treatment Ability Improvement Project for Diagnosing and Treating Intractable Diseases. Cord blood stem cell transplantation technology has entered the international advanced ranks and is currently the center with the largest number of cord blood transplantation cases in the world; functional neurosurgery such as epilepsy and Parkinson’s disease surgical treatment, liver transplantation, precision hepatectomy, laparoscopic hepatobiliary surgery, lateral Directly anterior approach hip arthroplasty (LDAA) and other technologies in the supine position are leading domestically. The research and treatment in the field of diabetes won the "Scientific Contribution Award", the highest academic award of the Diabetes Branch of the Chinese Medical Association. The number of CRT technology cases in cardiovascular medicine ranks first in the country.

 The hospital is the Clinical School of University of Science and Technology of China; it is a joint training center for doctoral students of Tianjin Medical University, an Anhui Medical Postgraduate Training Base of Shandong University, Affiliated Hospital of Anhui Medical University, Teaching Hospital of Wannan Medical University, and a joint teaching base for master students of Henan Xinxiang Medical University . There are the first post-doctoral workstation in Anhui Province in hospitals in the province, 53 master and doctoral teaching centers, and 247 doctoral and master supervisors. Selected into the first batch of national clinical teaching and training demonstration centers, with 34 national standardized training bases for resident physicians, the first batch of national standardized training bases for neurosurgery and cardiovascular disease specialists, and the fourth-level training base for gynecological endoscopy by the National Health and Family Planning Commission. The first batch of stroke screening and prevention bases in Anhui Province, the first national physician qualification examination practice skills examination and examiner training base in Anhui Province, the first batch of professional and technical personnel continuing education bases in Anhui Province, the first batch of general practitioners teacher training bases in Anhui Province, The first glioma diagnosis and treatment center in Anhui Province, and the American Heart Association cardiovascular first aid training base.

 Since 2010, we have provided equipment for the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital): SCA502U